Mutational analysis of the DNA binding domain A of chromosomal protein HMG1
نویسندگان
چکیده
منابع مشابه
Mutational analysis of the DNA binding domain A of chromosomal protein HMG1.
We have mutated several residues of the first of the two HMG-boxes of mammalian HMG1. Some mutants cannot be produced in Escherichia coli, suggesting that the peptide fold is grossly disrupted. A few others can be produced efficiently and have normal DNA binding affinity and specificity; however, they are more sensitive towards heating and chaotropic agents than the wild type polypeptide. Signi...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1994
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/22.3.285